If you have email sends logged in your account you can segment down on those email sends. To segment on emails go to Audience > Search.
Then choose: Activity > Email Send. You can select from any of the following criteria: Emailing, Timeframe, Organization, Service Used, Has Opened, Has Clicked, Clicked URL, Has Bounced, Has Unsubscribed, or Spam Complaint.
After you've made your email criteria selections, click "Save Selections" and proceed with editing your segment.